Hormone Therapy

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Information
Drug Name
Hormone Therapy
Description
Entry(CIViC)
5
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
breast cancer ESR1 p.Leu536Gln (p.L536Q)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 ) ESR1 p.Leu536Gln (p.L536Q)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 )
D Predictive Supports Resistance Somatic 3 24185512 Detail
breast cancer ESR1 p.Asp538Gly (p.D538G)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 ) ESR1 p.Asp538Gly (p.D538G)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 )
D Predictive Supports Resistance Somatic 3 24185512 Detail
breast cancer ESR1 p.Tyr537Cys (p.Y537C)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 ) ESR1 p.Tyr537Cys (p.Y537C)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 )
D Predictive Supports Resistance Somatic 3 24185512 Detail
breast cancer ESR1 p.Tyr537Asn (p.Y537N)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 ) ESR1 p.Tyr537Asn (p.Y537N)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 )
D Predictive Supports Resistance Somatic 3 24185512 Detail
breast cancer ESR1 p.Tyr537Ser (p.Y537S)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 ) ESR1 p.Tyr537Ser (p.Y537S)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 )
D Predictive Supports Resistance Somatic 3 24185512 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
MCF7 cell lines harboring the L536Q mutation in th... ESR1 ESR1 p.Leu536Gln (p.L536Q)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 ) ESR1 p.Leu536Gln (p.L536Q)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 )
Resitance or Non-Reponse true CIViC Evidence detail
MCF7 cell lines harboring the D538G mutation in th... ESR1 ESR1 p.Asp538Gly (p.D538G)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 ) ESR1 p.Asp538Gly (p.D538G)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 )
Resitance or Non-Reponse true CIViC Evidence detail
MCF7 cell lines harboring the Y537C mutation in th... ESR1 ESR1 p.Tyr537Cys (p.Y537C)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 ) ESR1 p.Tyr537Cys (p.Y537C)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 )
Resitance or Non-Reponse true CIViC Evidence detail
MCF7 cell lines harboring the Y537N mutation in th... ESR1 ESR1 p.Tyr537Asn (p.Y537N)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 ) ESR1 p.Tyr537Asn (p.Y537N)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 )
Resitance or Non-Reponse true CIViC Evidence detail
MCF7 cell lines harboring the L537S mutation in th... ESR1 ESR1 p.Tyr537Ser (p.Y537S)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 ) ESR1 p.Tyr537Ser (p.Y537S)
( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 )
Resitance or Non-Reponse true CIViC Evidence detail
NCT ID Status Phase Summary Start date Completion date
NCT04619069 Active, not recruiting Phase 1/Phase 2 Intermittent Androgen Deprivation Therapy With or Without Stereotactic Body Radiotherapy for Molecularly Identified Hormone Sensitive Oligometastatic Prostate Cancer October 27, 2020 October 2027
NCT04024462 Active, not recruiting Phase 3 A Two-Arm Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Subcutaneous Administration of the Fixed-Dose Combination of Pertuzumab and Trastuzumab in Combination With Chemotherapy in Chinese Participants With HER2-Positive Early Breast Cancer February 5, 2020 November 11, 2025
NCT02366130 Completed Phase 2 Trial of Ra-223 Dichloride in Combination With Hormonal Therapy and Denosumab in the Treatment of Patients With Hormone-Positive Bone-Dominant Metastatic Breast Cancer February 11, 2015 December 16, 2020
NCT00044291 Completed Phase 3 Phase III Study of Atamestane Plus Toremifene Versus Letrozole in Advanced Breast Cancer June 2002 January 2006
NCT03493854 Completed Phase 3 A Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Subcutaneous Administration of the Fixed-Dose Combination of Pertuzumab and Trastuzumab in Combination With Chemotherapy in Participants With HER2-Positive Early Breast Cancer June 14, 2018 June 2, 2023
NCT06083766 Recruiting Metabolic and Physiologic Responses to Hormone Therapy in Transgender and Gender Diverse People January 4, 2024 July 2026
NCT04134260 Recruiting Phase 3 Testing the Addition of the Drug Apalutamide to the Usual Hormone Therapy and Radiation Therapy After Surgery for Prostate Cancer March 5, 2020 November 1, 2026
NCT04915508 Recruiting Phase 2 Extremely Hypofractionated Intensity Modulated Stereotactic Body Radiotherapy for the Treatment of Prostate Cancer With Rising PSA After Radical Prostatectomy June 23, 2021 August 1, 2027
NCT05041842 Recruiting Phase 2 Treatment With Tucatinib in Patients With an Isolated Brain Progression of a Metastatic Breast Cancer December 17, 2021 March 30, 2026
NCT05448547 Recruiting Phase 3 Immediate Curative vs Conservative Treatment in Older Men With M0, High-risk Prostate Cancer November 4, 2022 December 31, 2036
NCT05717166 Recruiting Phase 3 A Randomized Phase III Trial of Stereotactic Ablative Radiotherapy for Patients With Up to 10 Oligometastases and a Synchronous Primary Tumor. October 6, 2023 April 2029
NCT00097344 Terminated Phase 3 The CAT Study: Atamestane Plus Toremifene Versus Letrozole in Advanced Breast Cancer December 2004 August 2006
NCT02855632 Unknown status N/A The Efficacy of G-CSF Against Adhesion Reformation After Hysteroscopic Adhesiolysis August 2016 December 2019
NCT00227773 Withdrawn Phase 2 Vatalanib and Octreotide in Treating Patients With Progressive Neuroendocrine Tumors
NCT00003517 Withdrawn Phase 2 Antineoplaston Therapy in Treating Patients With Stage III or Stage IV Prostate Cancer
NCT00080613 Withdrawn Phase 2 Neoadjuvant and Adjuvant Exemestane in Treating Postmenopausal Women With Locally Advanced Hormone Receptor-Positive Breast Cancer